Skin pigmentation from sweat

If you are a subscriber, please sign in 'My Account' at the top right of the screen. If you want to subscribe to this journal, see our rates. Photobiology, Phototherapy, and Photosensitivity Diseases.

UVA1 exposure leads to darken human skins of different constitutive pigmentation together with a molecular biologic impact. Contact Help Who are we? As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data. No hyperelasticity of the skin, post-traumatic hyperpigmentation or fibrous nodules were detected. Aucune hyperélasticité de la peau, zone d' hyperpigmentation post-traumatique ou nodules fibreux ne sont relevés.

Complications such as transitory hyperpigmentation or hypopigmentation are rare. Les complications telles qu' hyperpigmentation transitoire ou hypopigmentation - sont rares.

It also has slimming properties and can also be used against skin hyperpigmentation. Elle est également amincissante et permet de lutter contre les phénomènes d' hyperpigmentation de la peau.

Reports have been received of localised hypopigmentation and hyperpigmentation following imiquimod cream use.

Des cas d'hypopigmentation et d' hyperpigmentation localisées ont été rapportés après utilisation de la crème imiquimod. Acanthosis nigricans is a hyperpigmentation of the skin. Les acanthosis nigricans sont une hyperpigmentation de la peau. Troubles dermatologiques hyperpigmentation photosensible, ulcération intertrigineuse de type aphteuse et dermatose vésiculobulleuse.

Acanthosis nigricans, dry skin, hyperpigmentationmacular rash, sweating night or cold sweatvesicular rash. Affections de la peau et du tissu sous-cutané: acanthosis nigricans, sécheresse cutanée, hyperpigmentationéruption maculaire, hypersudation sueurs nocturnes ou sueurs froideséruption vésiculaire.

Pigmentation concerns can be broken into hypopigmentation light patches and hyperpigmentation dark patches. Les soucis de pigmentation peuvent se diviser en hypopigmentation plaques légères et hyperpigmentation taches sombres. Make the most of green tea polyphenols and catechins to prevent hyperpigmentation from sun damage that can leave you skin looking blotchy and older. Outside of the tropics, consideration of the pattern of UVB is relevant because only some wavelengths of UVB between and nm, with peak synthesis between and nm catalyse production of vitamin D in the skin.

Within the tropics, average UVB is high and has two equinoctial peaks, but outside of the tropics, average UVB levels are lower and exhibit but a single peak at the Summer Solstice [ 60 ]. Because eumelanin in skin is a highly effective sunscreen, the potential for cutaneous vitamin D production is reduced by dark skin [ 2163 — 66 ].

Darkly pigmented hominins dispersing out of equatorial Africa thus faced conditions that significantly affected their vitamin D physiology. Pre-vitamin D production occurs in skin of all colours, but in eumelanin-rich skin, low doses of UVB do not raise 25 OH D levels to physiologically adequate levels at which storage can take place; higher doses over longer periods of time are required for this, and these conditions are not met outside of equatorial latitudes.

Long-term occupation of non-tropical latitudes, thus, would not have been possible without loss of some constitutive eumelanin pigmentation in order to prevent the serious sequelae of vitamin D deficiency [ 21 ]. At extreme high latitudes, year-round occupation is not possible without a diet that is centred on consumption and storage of vitamin-D rich foods such as oily fish, marine mammals, or caribou and reindeer, which concentrate vitamin D in their muscle meat and fat [ 2170 ].

Melanin produced by the tanning response is the outcome of UV-induced stress and is regulated by melanocortins in the skin [ 71 ].

Melanocortins in the skin reduce the production of reactive oxygen species, enhance repair of DNA damage caused by UVR and inaugurate eumelanin synthesis in individuals who carry specific, naturally expressed variants of MC1R [ 71 ].

Tanning is thus a response to damage caused by UVR. Contrary to popular belief, tanned skin affords little or no protection from damage from subsequent UVR exposure. Recent experimental studies have shown that a tan developed under suberythemal UVB exposure provides minimal photoprotection, but a tan developed under UVA-rich sunlamps such as those used in tanning salons provided no photoprotective benefit [ 72 — 74 ].

Depigmented skin evolved not once, but multiple times in human history, and was accomplished by different combinations of genetic mutations. For modern European populations, different signatures of selection on the MC1R and SLC24A5 genes imply that both natural selection and genetic drift contributed to the evolution of depigmented skin. These genetic changes affected the amounts of melanin being produced in melanocytes and the size of the melanosomes in which the melanin was packaged [ 75 ]. For modern eastern Asian populations, depigmentation was not achieved through mutations at winter wonderland edinburgh rides SLC24A5 locus [ 75 ], but via a different set of genetic changes, which are still incompletely known [ 7677 ].

The fact that depigmented skin evolved independently in the ancestors of modern Europeans and East Asians suggests that at least two and probably more distinct genetic mutation events occurred and that multiple loci underwent positive selection in these two regions receiving relatively low levels of UVB [ 78 — 80 ]. The most likely reason for this was that it was associated with a loss of skin pigment that favoured vitamin D production under conditions of low UVB [ 697881 ]. Depigmented skin also evolved independently in Homo neanderthalensis [ 82 ] probably for the same reason.

There has been a cause and effect relationship between UVR and skin pigmentation in human evolution, and skin colour phenotypes have been modified under the action of natural selection to maintain an optimum balance between photoprotection and photosynthesis over spatially varying conditions of UVR.

Skin colour thus evolved as the product of two opposing clines, one emphasizing dark pigmentation and photoprotection against high loads of UVA and UVB near the equator, the other favouring depigmented skin to promote seasonal, UVB-induced photosynthesis of vitamin D 3 nearer the poles [ 60 ].

Intermediate latitudes with seasonally high loads of UVB favoured the evolution of people with intermediate colour capable of tanning [ 8485 ]. The most important points to reinforce here are that the geographical gradient of human skin colour evolved under the influence of natural selection, and that very similar skin colour phenotypes dark, light and intermediate have evolved independently numerous times under similar UVR conditions.

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Diverse combinations of skin colour genes occurred during the course of prehistory as the combined result of natural selection, gene flow due to migration, and founder effect or genetic drift due to population bottlenecks occurring in the course of dispersal events [ 6286 ]. Indigenous populations of the New World have generally lighter skin colours than those of the Old World, probably because they have not resided in their homelands for as long a time and because their adaptations to the environment have been more strongly cultural than biological, as exemplified by the wearing of sewn clothing and the making of shelters [ 212287 ].

Sexual selection does not appear to have been a major influence on the evolution of human skin coloration, but it probably did increase the degree of sexual dimorphism in skin colour in some populations [ 2187 ]. The unexposed skin of females is lighter than that of males in most populations [ 2183 ], possibly because of the greater need of females to produce vitamin D in the skin to absorb and mobilize calcium during pregnancy and lactation.

A persistent, directional preference for lighter-coloured females as marriage partners has been recognized during historic times in some east- and south-Asian cultures, and it is likely that this has contributed to the greater sexual dimorphism in coloration observed [ 2187 ]. Like skin, the coloration of human hair and eyes is determined primarily by the amount and type of melanin produced and stored in melanosomes [ 8889 ].

Iris pigmentation is also influenced by structural features within the eye itself and by the degree of pupillary dilation [ 90 — 92 ]. Although skin coloration varies according to the intensity and seasonality of UVR on a global scale, no such regular geographical pattern is observed with hair and eye coloration [ 93 ].

In fact, little variation in hair and eye coloration occurs in indigenous populations outside of Europe for hair and outside of Europe, North Africa, the Middle East, Central Asia and South Asia for eyes [ 888994 ]. The lack of variation in hair and eye coloration in Africa has been assumed to be caused by the importance of eumelanin in affording protection, as it does in the case of skin coloration, but this has not been empirically established. Hair and eye coloration appear to have not been under as strong natural selection as skin coloration, and loss of genetic variation at one or more population bottlenecks probably contributed to the patterns of phenotypic variation observed in the hair and irises of modern people [ 95 ].

Scalp hair in most non-European populations is very dark brown, with little phenotypic variation [ 96 ]. Many genes appear to contribute to the dark brown hair colour phenotype [ 8893 ], and the relative importance of different loci is not yet known.

The relatively high prevalence of blond hair in Northern Island Melanesia has been traced to the 93C allele of the TYRP1 gene [ 9798 ], which has been dispersed throughout the region in the course of human colonization of the Southwest Pacific. In Europe, blond hair has been traced to establishment of variation in a regulatory enhancer of the KITLG gene, while red hair is produced by a specific range of variants of the MC1R locus [ 99 — ].

Sexual selection is thought to have influenced the high prevalence of blond- and red-hair phenotypes in Europe [ 93 ], but this has not been established empirically.

The nature and coloration of human male facial hair—beards and moustaches—have been a matter of curiosity and speculation, but little formal research [ 16, ]. Male facial hair, manifested as moustaches, cheek hair whiskers and beards, occurs in some male primates and appears to represent secondary sexual characteristics that evolved as amplified visual signals of rank, dominance and attractiveness [ 8].

This supports claims that age-related changes in human beard and moustache coverage and colour on the male face serve as honest signals of age or social dominance [ ], and that they evolved as products of contest competition between males [ ].

Beards augment the effectiveness of human aggressive facial displays, but are rated as ambivalent or unattractive by females []. Until very recently, studies of human iris coloration focused primarily on European populations, where the greatest range and variety of eye colours—from dark brown to pale blue—are found.

Iris colour phenotypes are determined by amounts of melanin and by the ratio of eumelanin to phaeomelanin in the iris, with brown eyes having a higher ratio than light eyes [ 8889 ]. Other categorical eye colours, such as blue, green and hazel, are common in Europe and parts of the Middle East, and Central and South Asia, with Europeans having the lightest eye colours [ 88 ].

The sets of genetic markers associated with variation in iris coloration in Europe, South Asia and East Asia are distinct, and relatively little is known of the combination of evolutionary forces—including natural and sexual selection—that influenced their distribution [ 89 ]. Dark iris coloration is associated with less scattering of intraocular light, a trait that may be protective under conditions of bright sunlight and high UVR.

Blue eye coloration, on the other hand, is associated with greater intraocular light scattering and a higher level of melatonin suppression, traits that may have been adaptive under highly seasonal sunshine regimes in northwestern Eurasia [ ].

Blue-eyed women have been found to be preferred by blue-eyed men, possibly as a manifestation of a male adaptation for the detection of extra-pair paternity based on eye colour, as a phenotypically based assurance of paternity [ ]. Arguments for the action of natural and sexual selection on iris colour need to be examined with great care as more data on the yy comment perdre du poids basis of the trait are revealed.

A recent study showing that the genetic markers associated with iris coloration are also associated with skin and hair pigmentation traits suggests that iris coloration was a pleitropic effect associated with selection on pigmentation genes whose primary effect was skin or hair pigmentation, not iris coloration [ 89 ].

The genetic basis of human coloration is complex because some genetic variants affect all pigmentary systems—skin, hair and eyes—through pleiotropic effects, while others affect only one type [ ] and because different genes and gene combinations can create similar coloration phenotypes.

Despite the technical difficulties of such studies, the fascination of humans with their own coloration phenotypes will certainly continue to propel research forward quickly. Skin, hair and eye coloration in humans is variable, and has been influenced by different combinations of evolutionary forces. Skin coloration has been strongly influenced by natural selection, globally and throughout human prehistory, because of the importance of melanin as a natural sunscreen on naked skin.

The role of natural selection in the evolution of hair and eye coloration appears to have been negligible, but genetic bottlenecks followed by sexual selection may have played more significant roles in establishing the patterns of variation recognized outside of Africa. In recent centuries, humans have migrated faster and over longer distances than during any time in prehistory. Many of these movements have brought people into regions with markedly different solar regimes than their homelands.

Many people now live under levels of solar radiation that are much stronger, or much weaker and more seasonal, than those under which their ancestors evolved. These rapid changes in living circumstances have created significant health problems resulting from too much UVR exposure skin cancer, accelerated ageing of the skin and from too little UVR exposure vitamin D deficiency and its many sequelae that have greatly impacted individual well-being and public health.

Mitigating these problems is now the focus of considerable attention in many health professions [ — ]. Rapid, long-distance migrations have also brought people together from disparate and widely separated places, creating unprecedented and novel opportunities for gene flow.

The twenty-first century world contains a sepia rainbow of human skin colours, created from old and new combinations of skin colour—related genetic markers.

The effects of these new genetic admixtures on health are not known.

More significant to health and overall human well-being, however, are the problems of social segregation and behavioural bias that are rooted in cultural constructions of skin colour—based race categories [ 87 ]. Humans are visually oriented primates, and our varied colours are badges of our recently shared evolutionary history.

Our skin colours unite us, not divide us. Tim and two anonymous reviewers provided excellent suggestions for improvement of this contribution.

We thank Theresa Wilson of Penn State for providing comprehensive support and assistance to our research programme, including the maintenance of our reference library and preparation of this manuscript. The authors contributed equally to the conception and design of this paper and to the drafting and revising of the article for important intellectual content; they also gave the final approval of the version to be published. National Center for Biotechnology InformationU. Published online May Nina G.

Jablonski and George Chaplin. Author information Article notes Copyright and License information Disclaimer. Accepted Dec 9. This article has been cited by other articles in PMC. Abstract Humans are a colourful species of primate, with human skin, hair and eye coloration having been influenced by a great variety of evolutionary forces throughout prehistory. Keywords: eumelanin, phaeomelanin, ultraviolet radiation, natural selection, sexual selection, genetic drift.

Introduction Discussions of the cardinal features of the human lineage usually focus on bipedalism, relative brain size, language and technology, and ignore the remarkable distinctions of the integument and eyes that have figured importantly in human evolution. Human coloration in context Like most mammals, primates have hair covering most of their bodies.

Variation in human skin coloration is mostly a product of natural selection Skin colour as measured by skin reflectance and levels of UVR are highly correlated. Hair and eye coloration are not under strong natural selection Like skin, the coloration of human hair and eyes is determined primarily by the amount and type of melanin produced and stored in melanosomes [ 8889 ].

Conclusion Skin, hair and eye coloration in humans is variable, and has been influenced by different combinations of evolutionary forces. Authors' contributions The authors contributed equally to the conception and design of this paper and to the drafting and revising of the article for important intellectual content; they also gave the final approval of the version to be published. Competing interests We have no competing interests. Funding We received no funding for this study.

References 1. Caro T. The colours of extant mammals. Cell Dev. Walsberg GE. Consequences of skin color and fur properties for solar heat gain and ultraviolet irradiance in two mammals. B— The adaptive significance of coloration in mammals. BioScience 55— Body temperature, thermoregulatory behaviour and pelt characteristics of three colour morphs of springbok Antidorcas marsupialis.

A— Chaplin G, Jablonski NG. The integument of the odd-nosed colobines. In The natural history of the Doucs and snub-nosed monkeys ed. Jablonski NG, editor. Singapore: World Scientific Publishing Co. The primate palette: the evolution of primate coloration. Contrasting coloration in terrestrial mammals. Kingdon JS. The role of visual signals and face patterns in African forest monkeys guenons of the genus Cercopithecus.

Structural colouration of mammalian skin: convergent evolution of coherently scattering dermal collagen arrays. Sexual swellings advertise female quality in wild baboons. Nature— Nunn CL.

Skin pigmentation from sweat

The evolution of exaggerated sexual swellings in primates and the graded-signal hypothesis. Familiarity affects the assessment of female facial signals of fertility by free-ranging male rhesus macaques. Social correlates of testosterone and ornamentation in male mandrills.